Everyone needs to make sure that they have all Microsoft Updates in place, and that their Anti-Virus systems are working and current.
Here in NZ a number of organisations got hit hard with the earlier outbreak. See:
- April Fools: Conficker virus set to spread
- Conficker's next move a mystery to researchers
- Infected ministry had no Microsoft support contract
A free tool to detect infected or vulnerable computers is available for system admins from prominent Computer Security firm Eeye